1) Clinical usefulness of a deep learning-based system as the first screening on small-bowel ）capsule endoscopy reading.
Aoki T, Yamada A, Aoyama K, Saito H, Fujisawa G, Odawara N, Kondo R, Tsuboi A, Ishibashi R, Nakada A, Niikura R, Fujishiro M, Oka S, Ishihara S, Matsuda T, Nakahori M, Tanaka S, Koike K, Tada T.
Dig Endosc 2020; 32: 585-591


2) Automatic detection of blood content in capsule endoscopy images based on a deep convolutional neural network.
Aoki T, Yamada A, Kato Y, Saito H, Tsuboi A, Nakada A, Niikura R, Fujishiro M, Oka S, Ishihara S, Matsuda T, Nakahori M, Tanaka S, Koike K, Tada T.
J Gastroenterol Hepatol 2020; 35: 1196-1200

3) Oxyntic gland neoplasm of the stomach: expanding the spectrum and proposal of terminology.
Ushiku T, Kunita A, Kuroda R, Shinozaki-Ushiku A, Yamazawa S, Tsuji Y, Fujishiro M, Fukayama M.
Mod Pathol. 2020 Feb;33(2):206-216.

4) Steroid injection and polyglycolic acid shielding to prevent stricture after esophageal endoscopic submucosal dissection: a retrospective comparative analysis (with video).
Sakaguchi Y, Tsuji Y, Shinozaki T, Ohki D, Mizutani H, Minatsuki C, Niimi K, Yamamichi N, Koike K.
Gastrointest Endosc. 2020 Dec;92(6):1176-1186.e1. doi: 10.1016/j.gie.2020.04.070. Epub 2020 May 4.Gastrointest Endosc. 2020. PMID: 32376336

5) Expert endoscopists with high adenoma detection rates frequently detect diminutive adenomas in proximal colon.
Toyoshima O, Nishizawa T, Yoshida S, Sekiba K, Kataoka Y, Hata K, Watanabe H, Tsuji Y, Koike K.
Endosc Int Open. 2020 Jun;8(6):E775-E782. doi: 10.1055/a-1136-9971. Epub 2020 May 25.Endosc Int Open. 2020. PMID: 32490163 Free PMC article.

6) The exceptional performance of deep learning for capsule endoscopy: Will such quality be maintained in clinical scenarios?
Aoki T, Yamada A, Koike K.
Gastrointest Endosc 2020; 93: 365-366

7) Automatic detection of different types of small-bowel lesions on capsule endoscopy images using a newly developed deep convolutional neural network.
Otani K, Nakada A, Kurose Y, Niikura R, Yamada A, Aoki T, Nakanishi H, Doyama H, Hasatani K, Sumiyoshi T, Kitsuregawa M, Harada T, Koike K.
Endoscopy 2020; 52: 786-791.

8) Prediction model of bleeding after endoscopic submucosal dissection for early gastric cancer: BEST-J score.
Hatta W, Tsuji Y, Yoshio T, Kakushima N, Hoteya S, Doyama H, Nagami Y, Hikichi T, Kobayashi Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Koike T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Sugimoto M, Yamaguchi S, Michida T, Yada T, Asahina Y, Narasaka T, Kuribasyashi S, Kiyotoki S, Mabe K, Nakamura T, Nakaya N, Fujishiro M, Masamune A.
Gut. 2020 Jun 4: gutjnl-2019-319926. Online ahead of print.

9) The association of Helicobacter pylori infection with serum lipid profiles: An evaluation based on a combination of meta-analysis and a propensity score-based observational approach.
Shimamoto T, Yamamichi N, Gondo K, Takahashi Y, Takeuchi C, Wada R, Mitsushima T, Koike K.
PLoS One. 2020 Jun 8;15(6): e0234433.

10) Utilizing artificial intelligence in endoscopy: a clinician's guide.
Namikawa K, Hirasawa T, Yoshio T, Fujisaki J, Ozawa T, Ishihara S, Aoki T, Yamada A, Koike K, Suzuki H, Tada T .
Expert Rev Gastroenterol Hepatol 2020; 14: 689-706

11) Automatic detection and classification of protruding lesions in wireless capsule endoscopy images based on a deep convolutional neural network.
Saito H, Aoki T, Aoyama K, Kato Y, Tsuboi A, Yamada A, Fujishiro M, Oka S, Ishihara S, Matsuda T, Nakahori M, Tanaka S, Koike K, Tada T.
Gastrointest Endosc 2020; 92: 144-151.e1

12) Inverse time trends of peptic ulcer and reflux esophagitis show significant association with reduced prevalence of Helicobacter pylori infection.
Yamamichi N, Yamaji Y, Shimamoto T, Takahashi Y, Majima K, Wada R, Mitsushima T, Koike K.
Ann Med. 2020 Jun 22:1-9. Online ahead of print.

13) Highly accurate artificial intelligence systems to predict the invasion depth of gastric cancer: efficacy of conventional white-light imaging, nonmagnifying narrow-band imaging, and indigo-carmine dye contrast imaging.
Nagao S, Tsuji Y, Sakaguchi Y, Takahashi Y, Minatsuki C, Niimi K, Yamashita H, Yamamichi N, Seto Y, Tada T, Koike K.
Gastrointest Endosc. 2020 Jun 25:S0016-5107(20)34511-9. Online ahead of print.

14) Artificial intelligence using a convolutional neural network for automatic detection of small-bowel angioectasia in capsule endoscopy images.
Tsuboi A, Oka S, Aoyama K, Saito H, Aoki T, Yamada A, Matsuda T, Fujishiro M, Ishihara S, Nakahori M, Koike K, Tanaka S, Tada T.
Dig Endosc 2020; 32: 382-390.

15) GPR30-Expressing Gastric Chief Cells Do Not Dedifferentiate But Are Eliminated via PDK-Dependent Cell Competition During Development of Metaplasia.
Hata M, Kinoshita H, Hayakawa Y, Konishi M, Tsuboi M, Oya Y, Kurokawa K, Hayata Y, Nakagawa H, Tateishi K, Fujiwara H, Hirata Y, Worthley DL, Muranishi Y, Furukawa T, Kon S, Tomita H, Wang TC, Koike K.
Gastroenterology. 2020 May;158(6):1650-1666.e15.

16) Expert endoscopists with high adenoma detection rates frequently detect diminutive adenomas in proximal colon.
Toyoshima O, Nishizawa T, Yoshida S, Sekiba K, Kataoka Y, Hata K, Watanabe H, Tsuji Y, Koike K.
Endosc Int Open. 2020 Jun;8(6):E775-E782.

17) Nuclear staining of claudin-18 is a new immunohistochemical marker for diagnosing intramucosal well-differentiated gastric adenocarcinoma.
Takahashi Y, Tsutsumi Y, Takeuchi C, Shiogama K, Mizutani Y, Inada KI, Yamamichi N, Koike K.
Pathol Int. 2020 Jul 5. Epub ahead of print.

18) Hormonal suppression of stem cells inhibits symmetric cell division and gastric tumorigenesis.
Chang W, Wang H, Kim W, Liu Y, Deng H, Liu H, Jiang Z, Niu Z, Sheng W, Nápoles OC, Sun Y, Xu J, Sepulveda A, Hayakawa Y, Bass AJ, Wang TC.
Cell Stem Cell. May 7;26(5):739-754.e8. 2020.

19) Hypergastrinemia Expands Gastric ECL Cells Through CCK2R+ Progenitor Cells via ERK Activation.
Sheng W, Malagola E, Nienhüser H, Zhang Z, Kim W, Zamechek L, Sepulveda A, Hata M, Hayakawa Y, Zhao CM, Chen D, Wang TC.
Cell Mol Gastroenterol Hepatol. 10(2):434-449.e1. 2020

20) Endoscopic submucosal dissection for colorectal neoplasms in proximity or extending to a diverticulum.
Muramoto T, Ohata K, Sakai E, Takayanagi S, Kimoto Y, Suzuki Y, Ishii R, Kanda K, Negishi R, Takita M, Minato Y, Tsuji Y, Chiba H, Matsuhashi N.
Surg Endosc. 2020 Jul 15. Online ahead of print.

21) The simplified Kyoto classification score is consistent with the ABC method of classification as a grading system for endoscopic gastritis.
Nishizawa T, Toyoshima O, Kondo R, Sekiba K, Tsuji Y, Ebinuma H, Suzuki H, Tanikawa C, Matsuda K, Koike K..
J Clin Biochem Nutr. 2021 Jan;68(1):101-104. doi: 10.3164/jcbn.20-41. Epub 2020 Jul 16.J Clin Biochem Nutr. 2021. PMID: 33536719 Free PMC article.

22) Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche.
Middelhoff M, Nienhüser H, Valenti G, Maurer HC, Hayakawa Y, Takahashi R, Kim W, Jiang Z, Malagola E, Cuti K, Tailor Y, Zamechek LB, Renz BW, Quante M, Yan KS, Wang TC.
Nat Commun. Jan 8;11(1):111. 2020

23) Plasticity of Intestinal Epithelium: Stem Cell Niches and Regulatory Signals.
Kurokawa K, Hayakawa Y, Koike K.
Int J Mol Sci. Dec 31;22(1):357. 2020

24) FIGHT-Japan Study Group. Influence of anticoagulants on the risk of delayed bleeding after gastric endoscopic submucosal dissection: a multicenter retrospective study.
Tomida H, Yoshio T, Igarashi K, Morita Y, Oda I, Inoue T, Hikichi T, Sumiyoshi T, Doyama H, Tsuji Y, Nishikawa J, Hatta W, Mikami T, Iguchi M, Sumiyama K, Yamamoto K, Kitamura K, Kuribayashi S, Yanagitani A, Uraoka T, Yada T, Hasatani K, Kawaguchi K, Fujita T, Nishida T, Hiasa Y, Fujishiro M;
Gastric Cancer. 2020 Jul 18. Online ahead of print

25) Inflammatory fibroid polyp mimicking an early gastric cancer.
Nagao S, Tsuji Y, Sakaguchi Y, Ushiku T, Koike K.
Gastrointest Endosc. 2020 Jul;92(1):217-218.

26) The balance of stromal BMP signaling mediated by GREM1 and ISLR drives colorectal carcinogenesis.
Kobayashi H, Gieniec KA, Wright JA, Wang T, Asai N, Mizutani Y, Ida T, Ando R, Suzuki N, Lannagan TR, Ng JQ, Hara A, Shiraki Y, Mii S, Ichinose M, Vrbanac L, Lawrence MJ, Sammour T, Uehara K, Davies G, Lisowski L, Alexander IE, Hayakawa Y, Butler LM, Zannettino ACW, Din MO, Hasty J, Burt AD, Leedham SJ, Rustgi AK, Mukherjee S, Wang TC, Enomoto A, Takahashi M, Worthley DL, Woods SL.
Gastroenterology. Nov 14:S0016-5085(20)35400-7. 2020

27) PD-1 Signaling Promotes Tumor-Infiltrating Myeloid-Derived Suppressor Cells and Gastric Tumorigenesis in Mice.
Kim W, Chu TH, Nienhüser H, Jiang Z, Del Portillo A, Remotti HE, White RA, Hayakawa Y, Tomita H, Fox JG, Drake CG, Wang TC.
Gastroenterology. Oct 28:S0016-5085(20)35325-7. 2020

28) A Novel Technique of Endoscopic Papillectomy with Hybrid Endoscopic Submucosal Dissection for Ampullary Tumors: A Proof-of-Concept Study (with Video).
Takahara N, Tsuji Y, Nakai Y, Suzuki Y, Inokuma A, Kanai S, Noguchi K, Sato T, Hakuta R, Ishigaki K, Saito K, Sakaguchi Y, Saito T, Hamada T, Mizuno S, Kogure H, Koike K.
J Clin Med. 2020 Aug 18;9(8): E2671.

29) Nuclear staining of claudin-18 is a new immunohistochemical marker for diagnosing intramucosal well-differentiated gastric adenocarcinoma.
Takahashi Y, Tsutsumi Y, Takeuchi C, Shiogama K, Mizutani Y, Inada KI, Yamamichi N, Koike K.
Pathol Int. 2020 Sep;70(9):644-652. doi: 10.1111/pin.12978. Epub 2020 Jul 5.Pathol Int. 2020. PMID: 32623829

30) Deletion of Histone Methyltransferase G9a Suppresses Mutant Kras-driven Pancreatic Carcinogenesis.
Kato H, Tateishi K, Fujiwara H, Ijichi H, Yamamoto K, Nakatsuka T, Kakiuchi M, Sano M, Kudo Y, Hayakawa Y, Nakagawa H, Tanaka Y, Otsuka M, Hirata Y, Tachibana M, Shinkai Y, Koike K.
Cancer Genomics Proteomics. Nov-Dec; 17(6):695-705. 2020

31) Distinct Features of Autoimmune Gastritis in Patients with Open-Type Chronic Gastritis in Japan.
Tsuboi M, Niikura R, Hayakawa Y, Hirata Y, Ushiku T, Koike K.
Biomedicines. Oct 14;8(10):419. 2020

32) Endoscopy-based Kyoto classification score of gastritis related to pathological topography of neutrophil activity.
Toyoshima O, Nishizawa T, Yoshida S, Sakaguchi Y, Nakai Y, Watanabe H, Suzuki H, Tanikawa C, Matsuda K, Koike K.
World J Gastroenterol. 2020 Sep 14;26(34):5146-5155. doi: 10.3748/wjg.v26.i34.5146　PMID: 32982115 Free PMC article.

33) Mist1+ gastric isthmus stem cells are regulated by Wnt5a and expand in response to injury and inflammation in mice.
Nienhüser H, Kim W, Malagola E, Ruan T, Valenti G, Middelhoff M, Bass A, Der CJ, Hayakawa Y, Wang TC.
Gut. Jul 24:gutjnl-2020-320742. 2020

34) Tumor microenvironment in gastric cancers.
Oya Y, Hayakawa Y*, Koike K.
Cancer Sci. Aug;111(8):2696-2707. 2020

35) Interleukin-1β-induced pancreatitis promotes pancreatic ductal adenocarcinoma via B lymphocyte-mediated immune suppression.
Takahashi R, Macchini M, Sunagawa M, Jiang Z, Tanaka T, Valenti G, Renz BW, White RA, Hayakawa Y, Westphalen CB, Tailor Y, Iuga AC, Gonda TA, Genkinger J, Olive KP, Wang TC.
Gut. Feb;70(2):330-341. 2020

36) Dysregulated Immune Responses by ASK1 Deficiency Alter Epithelial Progenitor Cell Fate and Accelerate Metaplasia Development during H. pylori Infection.
Hayakawa Y, Hirata Y, Hata M, Tsuboi M, Oya Y, Kurokawa K, Abe S, Arai J, Suzuki N, Nakagawa H, Fujiwara H, Tateishi K, Maeda S, Koike K.
Microorganisms. 8(12) 2020

37) Automatic detection of colorectal neoplasia in wireless colon capsule endoscopic images using a deep convolutional neural network.
Yamada A, Niikura R, Otani K, Aoki T, Koike K.
Endoscopy 2020 Sep 18. Online ahead of print.

38) Risk for lymph node metastasis in Epstein-Barr virus-associated gastric carcinoma with submucosal invasion.
Tsuji Y, Ushiku T, Shinozaki T, Yamashita H, Seto Y, Fukayama M, Fujishiro M, Oda I, Katai H, Taniguchi H, Hasatani K, Kaizaki Y, Oga A, Nishikawa J, Akasaka R, Endo M, Sugai T,
Matsumoto T, Koike K. Dig Endosc. 2021 May;33(4):592-597. doi: 10.1111/den.13823. Epub 2020 Oct 19.Dig Endosc. 2021. PMID: 32852875

1） Automatic detection of erosions and ulcerations in wireless capsule endoscopy images based on a deep convolutional neural network.
Aoki T, Yamada A, Aoyama K, Saito H, Tsuboi A, Nakada A, Niikura R, Fujishiro M, Oka S, Ishihara S, Matsuda T, Tanaka S, Koike K, Tada T.
Gastrointest Endosc 2019; 89: 357-363
2） Development and internal validation of a risk scoring system for gastrointestinal events requiring surgery in gastrointestinal lymphoma patients.
Aoki T, Yamada A, Takahashi M, Niikura R, Toyama K, Ushiku T, Kurokawa M, Momose T, Fukayama M, Koike K.
J Gastroenterol Hepatol 2019; 34: 693-699

3） Traction-assisted esophageal endoscopic submucosal dissection for treatment of squamous cell carcinoma involving a diverticulum.
Tsuji Y, Sa Oxyntic gland neoplasm of the stomach: expanding ito I, Koike K.
Dig Endosc. 2019 Jan;31(1):e7-e8.

4） The Effects of Direct Oral Anticoagulants, Warfarin, Aspirin and Thienopyridine on the Performance of Immunochemical, Faecal, Occult Blood Tests.
Niikura R, Yamada A, Fujishiro M, Tanaka K, Matsuda K, Saito Y, Ohtsuka K, Oda I, Katada C, Kato M, Kida M, Kobayashi K, Hoteya S, Horimatsu T, Kodashima S, Matsuda T, Muto M, Yamamoto H, Ryozawa S, Iwakiri R, Kutsumi H, Miyata H, Kato M, Haruma K, Fujimoto K, Uemura N, Kaminishi M, Shinozaki T, Tajiri H, Koike K.
Digestion. 2019;100(2):117-126.

5） Next endoscopic approach for acute lower gastrointestinal bleeding without an identified source on colonoscopy: upper or capsule endoscopy?.
Aoki T, Nagata N, Yamada A, Shimbo T, Matsushita Y, Shimomura A, Kobayashi S, Moriyasu S, Niikura R, Sakurai T, Hirata Y, Akiyama J, Uemura N, Koike K.
Endosc Int Open 2019; 7: E337-E346

6） Analysis of predictive factors for R0 resection and immediate bleeding of cold snare polypectomy in colonoscopy.
Aoki T, Yoshida S, Abe H, Ono S, Nakada A, Ota Y, Narita A, Yoshikawa T, Kinoshita H, Tsuji Y, Yamada A, Fujishiro M, Hirata Y, Fukayama M, Koike K.
PLoS One 2019; 14: e0213281

7） Long-term outcomes of endoscopic resection and metachronous cancer after endoscopic resection for adenocarcinoma of the esophagogastric junction in Japan.
Abe S, Ishihara R, Takahashi H, Ono H, Fujisaki J, Matsui A, Takahashi A, Goda K, Kawada K, Koike T, Takeuchi M, Tsuji Y, Hirasawa D, Oyama T.
Gastrointest Endosc. 2019 Jun;89(6):1120-1128.


8） Endoscopic tissue shielding to prevent bleeding after endoscopic submucosal dissection: a prospective multicenter randomized controlled trial.
Kataoka Y, Tsuji Y, Hirasawa K, Takimoto K, Wada T, Mochizuki S, Ohata K, Sakaguchi Y, Niimi K, Ono S, Kodashima S, Yamamichi N, Fujishiro M, Koike K.
Endoscopy.2019 Jul;51(7):619-627.


9） Identification of marker genes and pathways specific to precancerous duodenal adenomas and early stage adenocarcinomas.
Sakaguchi Y, Yamamichi N, Tomida S, Takeuchi C, Kageyama-Yahara N, Takahashi Y, Shiogama K, Inada KI, Ichinose M, Fujishiro M, Koike K.
J Gastroenterol. 2019 Feb;54(2):131-140.

10） Role of early capsule endoscopy for acute GI bleeding.
Aoki T, Nagata N, Watanabe K, Niikura R, Yamada A, Koike K, Uemura N, Itoi T, Kawai T.
Gastrointest Endosc 2019; 90: 701-702

11） Initial management for acute lower gastrointestinal bleeding.
Aoki T, Hirata Y, Yamada A, Koike K.
World J Gastroenterol 2019; 25: 69-84

12） Management of adverse events related to endoscopic resection of upper gastrointestinal neoplasms: Review of the literature and recommendations from experts.
Yamamoto Y, Kikuchi D, Nagami Y, Nonaka K, Tsuji Y, Fujimoto A, Sanomura Y, Tanaka K, Abe S, Zhang S, De Lusong MA, Uedo N.
Dig Endosc. 2019 Apr;31 Suppl 1:4-20. doi: 10.1111/den.13388. PMID: 30994225.88.

13） Haemostasis treatment using dual red imaging during endoscopic submucosal dissection: a multicentre, open-label, randomised controlled trial.
Fujimoto A, Saito Y, Abe S, Hoteya S, Nomura K, Yasuda H, Matsuo Y, Uraoka T, Kuribayashi S, Saito I, Tsuji Y, Maehata T, Ochiai Y, Nishizawa T, Yahagi N.
BMJ Open Gastroenterol. 2019 Mar 30;6(1):e000275. doi: 10.1136/bmjgast-2019-000275. eCollection 2019.

14） Role of Muscarinic Acetylcholine Signaling in Gastrointestinal Cancers.
Konishi M, Hayakawa Y, Koike K.
Biomedicines. 2019 Aug 10;7(3). pii: E58.

15） Three types of metaplasia model through Kras activation, Pten deletion, or Cdh1 deletion in the gastric epithelium.
Kinoshita H, Hayakawa Y, Konishi M, Hata M, Tsuboi M, Hayata Y, Hikiba Y, Ihara S, Nakagawa H, Ikenoue T, Ushiku T, Fukayama M, Hirata Y, Koike K.
J Pathol. 2019 Jan;247(1):35-47.

16） Artificial Restriction DNA Cutter Using Nuclease S1 for Site‐Selective Scission of Genomic DNA
Rajendran A, Shigi N, Sumaoka J, Komiyama M.
Curr Protoc Nucleic Acid Chem. 2019 Mar;76(1):e72. doi: 10.1002/cpnc.72. Epub 2019 Feb 5.

17） Rajendran A, Shigi N, Sumaoka J, Komiyama M. Affinity Isolation of Defined Genomic Fragments Cleaved by Nuclease S1‐based Artificial Restriction DNA Cutter
Curr Protoc Nucleic Acid Chem. 2019 Mar;76(1):e76. doi: 10.1002/cpnc.76. Epub 2019 Feb 12.

18） Promotion of Single-Strand Invasion of PNA to Double-Stranded DNA by Pseudo-Complementary Base Pairing.
Shigi N, Mizuno Y, Kunifuda H, Matsumura K, Komiyama M.
Bull Chem Soc Jpn. 2019 FEB, 92(2):330-335. doi: 10.1246/bcsj.20180211

19） The Reduction in Gastric Atrophy after Helicobacter pylori Eradication Is Reduced by Treatment with Inhibitors of Gastric Acid Secretion.
Niikura R, Hayakawa Y, Hirata Y, Ogura K, Fujishiro M, Yamada A, Ushiku T, Konishi M, Fukayama M, Koike K.
Int J Mol Sci. 2019 Apr 18;20(8). pii: E1913.

20） Alpha-Blockers As Colorectal Cancer Chemopreventive: Findings from a Case-Control Study, Human Cell Cultures, and In Vivo Preclinical Testing.
Suzuki N, Niikura R, Ihara S, Hikiba Y, Kinoshita H, Higashishima N, Hayakawa Y, Yamada A, Hirata Y, Nakata R, Okamoto M, Sano M, Kushiyama A, Ichinose M, Woods SL, Worthley D, Iwamoto Y, Koike K.
Cancer Prev Res (Phila). 2019 Mar;12(3):185-194.

21） Detection of gastritis by a deep convolutional neural network from double-contrast upper gastrointestinal barium X-ray radiography.
Togo R, Yamamichi N, Mabe K, Takahashi Y, Takeuchi C, Kato M, Sakamoto N, Ishihara K, Ogawa T, Haseyama M.
J Gastroenterol. 2019 Apr;54(4):321-329.

22） A combination of serum anti-Helicobacter pylori antibody titer and Kyoto classification score could provide a more accurate diagnosis of H pylori.
Nishizawa T, Sakitani K, Suzuki H, Yamakawa T, Takahashi Y, Yamamichi N, Watanabe H, Seto Y, Koike K, Toyoshima O.
United European Gastroenterol J. 2019 Apr;7(3):343-348.

23） Detection of Premalignant Gastrointestinal Lesions Using Surface-Enhanced Resonance Raman Scattering-Nanoparticle Endoscopy.
Harmsen S, Rogalla S, Huang R, Spaliviero M, Neuschmelting V, Hayakawa Y, Lee Y, Tailor Y, Toledo-Crow R, Kang JW, Samii JM, Karabeber H, Davis RM, White JR, van de Rijn M, Gambhir SS, Contag CH, Wang TC, Kircher MF.
ACS Nano. 2019 Feb 26;13(2):1354-1364.

24） BHLHA15-Positive Secretory Precursor Cells Can Give Rise to Tumors in Intestine and Colon in Mice.
Hayakawa Y, Tsuboi M, Asfaha S, Kinoshita H, Niikura R, Konishi M, Hata M, Oya Y, Kim W, Middelhoff M, Hikiba Y, Higashijima N, Ihara S, Ushiku T, Fukayama M, Tailor Y, Hirata Y, Guha C, Yan KS, Koike K, Wang TC.
Gastroenterology. 2019 Mar;156(4):1066-1081.e16.

25） Initial and crucial genetic events in intestinal-type gastric intramucosal neoplasia.
Rokutan H, Abe H, Nakamura H, Ushiku T, Arakawa E, Hosoda F, Yachida S, Tsuji Y, Fujishiro M, Koike K, Totoki Y, Fukayama M, Shibata T.
J Pathol. 2019 Apr;247(4):494-504.

26） Tandem repeats of the 5' flanking region of human MUC5AC have a role as a novel enhancer in MUC5AC gene expression.
Kageyama-Yahara N, Yamamichi N, Takahashi Y, Takeuchi C, Matsumoto Y, Sakaguchi Y, Koike K.
Biochem Biophys Rep. 2019 Apr 4;18:100632.

27） Mutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation.
Fujiwara H, Tateishi K, Misumi K, Hayashi A, Igarashi K, Kato H, Nakatsuka T, Suzuki N, Yamamoto K, Kudo Y, Hayakawa Y, Nakagawa H, Tanaka Y, Ijichi H, Kogure H, Nakai Y, Isayama H, Hasegawa K, Fukayama M, Soga T, Koike K.
Sci Rep. Dec 11;9(1):18859. 2019

28） Detection of circulating colorectal cancer cells by a custom microfluid system before and after endoscopic metallic stent placement.
Ishibashi R, S Yoshida, N Odawara, T Kishikawa, R Kondo, A Nakada, R Hakuta, N Takahara, E Tanaka, K Sekiba, T Seimiya, T Ohnaga, M Otsuka, K Koike.
Oncol Lett 18 (6):6397-6404

29） Endoscopic shielding with polyglycolic acid sheets and fibrin glue for a large-sized ulcer after endoscopic submucosal dissection.
Tsuji Y, Sakaguchi Y, Koike K.
Dig Endosc. 2019 Apr;31 Suppl 1:23-24.

30） Red Fluorescence Probe Targeted to Dipeptidylpeptidase-IV for Highly Sensitive Detection of Esophageal Cancer.
Ogasawara A, Kamiya M, Sakamoto K, Kuriki Y, Fujita K, Komatsu T, Ueno T, Hanaoka K, Onoyama H, Abe H, Tsuji Y, Fujishiro M, Koike K, Fukayama M, Seto Y, Urano Y.
Bioconjug Chem. 2019 Apr 17;30(4):1055-1060.

31） New colorectal endoscopic submucosal dissection technique using a single tunnel: the "gateway" method.
Ohno A, Kato A, Kusuhara M, Miyamoto N, Arai K, Tsuji Y, Hisamatsu T.
Endoscopy. 2019 Jul 1.

32） Association between postprandial hyperglycemia at clinic visits and all-cause and cancer mortality in patients with type 2 diabetes: A long-term historical cohort study in Japan Takao T, Takahashi K, Suka M, Suzuki N, Yanagisawa H.
Diabetes Res Clin Pract. Feb;148:152-159.

33） Mouse Model for Cholangiocarcinoma from Peribiliary Glands
Nakagawa H, Suzuki N, Koike K.
Methods Mol Biol. 1905:237-245.

34） Endoscopic tissue shielding to prevent bleeding after endoscopic submucosal dissection: a prospective multicenter randomized controlled trial.
Kataoka Y, Tsuji Y, Hirasawa K, Takimoto K, Wada T, Mochizuki S, Ohata K, Sakaguchi Y, Niimi K, Ono S, Kodashima S, Yamamichi N, Fujishiro M, Koike K.
Endoscopy. 2019 Jul;51(7):619-627.

35） CF290 for pancolonic chromoendoscopy improved sessile serrated polyp detection and procedure time: a propensity score-matching study.
Toyoshima O, Yoshida S, Nishizawa T, Yamakawa T, Sakitani K, Hata K, Takahashi Y, Fujishiro M, Watanabe H, Koike K.
Endosc Int Open. 2019 Aug;7(8):E987-E993.

36） Site-specific Manipulation of Mitochondrial DNA by Artificial Restriction DNA Cutter.
Harumoto T, Shigi N, Tsumoto K, Komiyama M.
Chem Lett. 2019 Nov, 48(11): 1332-133. doi: 10.1246/cl.190572

1) Etiology and long-term rebleeding of endoscopic ulcerative lesions in the small bowel in patients with obscure gastrointestinal bleeding: A multicenter cohort study.
Aoki T, Yamada A, Hirata Y, Suzuki H, Nakada A, Niikura R, Seto M, Okamoto M, Koike K.
J Gastroenterol Hepatol 2018; 33: 1327-1334

2) External validation of the NOBLADS score, a risk scoring system for severe acute lower gastrointestinal bleeding.
Aoki T, Yamada A, Nagata N, Niikura R, Hirata Y, Koike K.
PLoS One 2018; 13: e0196514

3) A multicenter, randomized controlled trial comparing the identification rate of stigmata of recent hemorrhage and rebleeding rate between early and elective colonoscopy in outpatient-onset acute lower gastrointestinal bleeding: study protocol for a randomized controlled trial.　
Niikura R, Nagata N, Yamada A, Doyama H, Shiratori Y, Nishida T, Kiyotoki S, Yada T, Fujita T, Sumiyoshi T, Hasatani K, Mikami T, Honda T, Mabe K, Hara K, Yamamoto K, Takeda M, Takata M, Tanaka M, Shinozaki T, Fujishiro M, Koike K.　
Trials. 2018 Apr 3;19(1):214. doi: 10.1186/s13063-018-2558-y.　PMID: 29615078 Free PMC Article

4) Non-variceal upper gastrointestinal bleeding.　
Lanas A, Dumonceau JM, Hunt RH, Fujishiro M, Scheiman JM, Gralnek IM, Campbell HE, Rostom A, Villanueva C, Sung JJY.　
Nat Rev Dis Primers. 2018 Apr 19;4:18020. doi: 10.1038/nrdp.2018.20. Review.　PMID:29671413

5) Prediction of the Clinical Outcomes of Sigmoid Volvulus by Abdominal X-Ray: AXIS Classification System.
Ishibashi R, Niikura R, Obana N, Fukuda S, Tsuboi M, Aoki T, Yoshida S, Yamada A, Hirata Y, Koike K.
Gastroenterol Res Pract 2018 Nov 15;2018:8493235.

6) Gastric Stem Cell and Cellular Origin of Cancer.
Hata M, Hayakawa Y, Koike K.
Biomedicines. 2018 Oct 31;6(4).

7) Multidetector-Row Computed Tomography and Colonoscopy for Detecting a Rectal Dieulafoy Lesion as a Source of Lower Gastrointestinal Hemorrhage.
Kaneko M, Nozawa H, Tsuji Y, Emoto S, Murono K, Nishikawa T, Sasaki K, Otani K, Tanaka T, Hata K, Kawai K, Koike K.　
Case Rep Gastroenterol.  2018 Apr 27;12(1):202-206. doi: 10.1159/000488973. eCollection 2018 Jan-Apr.　PMID:29805367

8) Automatic anatomical classification of esophagogastroduodenoscopy images using deep convolutional neural networks.
Takiyama H, Ozawa T, Ishihara S, Fujishiro M, Shichijo S, Nomura S, Miura M, Tada T.
Sci Rep. 2018 May 14;8(1):7497. doi: 10.1038/s41598-018-25842-6.　PMID:29760397

9) Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness.
Renz BW, Tanaka T, Sunagawa M, Takahashi R, Jiang Z, Macchini M, Dantes Z, Valenti G, White RA, Middelhoff MA, Ilmer M, Oberstein PE, Angele MK, Deng H, Hayakawa Y, Westphalen CB, Werner J, Remotti H, Reichert M, Tailor YH, Nagar K, Friedman RA, Iuga AC, Olive KP, Wang TC. 
Cancer Discov. 2018 Nov;8(11):1458-1473.

10) Role of warfarin as a predictor of recurrent bleeding after negative small-bowel capsule endoscopy.
Niikura R, Yamada A, Hirata Y, Hayakawa Y, Suzuki H, Yamamoto S, Fujishiro M, Koike K. 
Gastrointest Endosc. 2018 Sep;88(3):574-574.e2.


11) Identification of marker genes and pathways specific to precancerous duodenal adenomas and early stage adenocarcinomas.
Sakaguchi Y, Yamamichi N, Tomida S, Takeuchi C, Kageyama-Yahara N, Takahashi Y, Shiogama K, Inada KI, Ichinose M, Fujishiro M, Koike K.　
J Gastroenterol. 2018 Jun 28. doi: 10.1007/s00535-018-1489-4. [Epub ahead of print]
PMID:299

12) The Tuft Cell-ILC2 Circuit Integrates Intestinal Defense and Homeostasis.
Hayakawa Y, Wang TC.
Cell. 2018 Jul 12;174(2):251-253.

13) Adhesive Interactions between Mononuclear Phagocytes and Intestinal Epithelium Perturb Normal Epithelial Differentiation and Serve as a Therapeutic Target in Inflammatory Bowel Disease.
Ihara S, Hirata Y, Hikiba Y, Yamashita A, Tsuboi M, Hata M, Konishi M, Suzuki N, Sakitani K, Kinoshita H, Hayakawa Y, Nakagawa H, Ijichi H, Tateishi K, Koike K.
J Crohns Colitis. 2018 Nov 9;12(10):1219-1231.

14) Gastroesophageal Reflux Disease-Related Disorders of Systemic Sclerosis Based on the Analysis of 66 Patients.　
Matsuda R, Yamamichi N, Shimamoto T, Sumida H, Takahashi Y, Minatsuki C, Kodashima S, Ono S, Niimi K, Tsuji Y, Sakaguchi Y, Saito I, Kataoka Y, Asada-Hirayama I, Kakimoto H, Yakabi S, Takeuchi C, Matsumoto Y, Tamaki Z, Fujishiro M, Asano Y, Sato S, Koike K.　
Digestion. 2018 Jul 25;98(4):201-208. doi: 10.1159/000489848. [Epub ahead of print]　PMID:30045036

15) Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis.
Lannagan TRM, Lee YK, Wang T, Roper J, Bettington ML, Fennell L, Vrbanac L, Jonavicius L, Somashekar R, Gieniec K, Yang M, Ng JQ, Suzuki N, Ichinose M, Wright JA, Kobayashi H, Putoczki TL, Hayakawa Y, Leedham SJ, Abud HE, Yilmaz ÖH, Marker J, Klebe S, Wirapati P, Mukherjee S, Tejpar S, Leggett BA, Whitehall VLJ, Worthley DL, Woods SL.
Gut. 2019 Apr;68(4):684-692. doi: 10.1136/gutjnl-2017-315920. Epub 2018 Apr 17.

16) Efficacy of Vonoprazan for Gastroesophageal Reflux Symptoms in Patients with Proton Pump Inhibitor-resistant Non-erosive Reflux Disease.
Niikura R, Yamada A, Hirata Y, Hayakawa Y, Takahashi A, Shinozaki T, Takeuchi Y, Fujishiro M, Koike K. 
Intern Med. 2018 Sep 1;57(17):2443-2450.

17) Short-Term Outcomes of Multicenter Prospective Cohort Study of Gastric Endoscopic Resection: "Real-World Evidence" in Japan.　
Suzuki H, Takizawa K, Hirasawa T, Takeuchi Y, Ishido K, Hoteya S, Yano T, Tanaka S, Endo M, Nakagawa M, Toyonaga T, Doyama H, Hirasawa K, Matsuda M, Yamamoto H, Fujishiro M, Hashimoto S, Maeda Y, Oyama T, Takenaka R, Yamamoto Y, Naito Y, Michida T, Kobayashi N, Kawahara Y, Hirano M, Jin M, Hori S, Niwa Y, Hikichi T, Shimazu T, Ono H, Tanabe S, Kondo H, Iishi H, Ninomiya M, Oda I; For J-WEB/EGC group.　
Dig Endosc. 2018 Jul 30. doi: 10.1111/den.13246. [Epub ahead of print]　PMID:30058258

18) The diagnostic outcomes of esophageal cancer by artificial intelligence using convolutional neural networks.
Horie Y, Yoshio T, Aoyama K, Yoshimizu S, Horiuchi Y, Ishiyama A, Hirasawa T, Tuchida T, Ozawa T, Ishihara S, Kumagai Y, Fujishiro M, Maetani I, Fujisaki J, Tada T.　
Gastrointest Endosc. 2018 Aug 15. pii: S0016-5107(18)32926-2. doi: 10.1016/j.gie.2018.07.037. [Epub ahead of print]　PMID:30120958

19) Distinct Chemopreventive Effects of Aspirin in Diffuse and Intestinal-Type Gastric Cancer.
Niikura R, Hayakawa Y, Hirata Y, Konishi M, Suzuki N, Ihara S, Yamada A, Ushiku T, Fujishiro M, Fukayama M, Koike K.
Cancer Prev Res (Phila). 2018 May;11(5):279-286.

20) Mature gastric chief cells are not required for the development of metaplasia.
Kinoshita H, Hayakawa Y, Niu Z, Konishi M, Hata M, Tsuboi M, Hayata Y, Hikiba Y, Ihara S, Nakagawa H, Hirata Y, Wang TC, Koike K. 
Am J Physiol Gastrointest Liver Physiol. 2018 May 1;314(5):G583-G596.

21) Early detection of gastric cancer after Helicobacter pylori eradication due to endoscopic surveillance.
Sakitani K, Nishizawa T, Arita M, Yoshida S, Kataoka Y, Ohki D, Yamashita H, Isomura Y, Toyoshima A, Watanabe H, Iizuka T, Saito Y, Fujisaki J, Yahagi N, Koike K, Toyoshima O.
Helicobacter. 2018 Aug;23(4):e12503.

22) A Case of an embedded clip in the gastric wall after shielding a post-endoscopic submucosal dissection ulcer with polyglycolic acid sheet.
Fukagawa K, Ono S, Koike K.
Dig Endosc. 2018 Sep;30(5):678.

23) Long-term proton pump inhibitor use is a risk factor of gastric cancer after treatment for Helicobacter pylori: a retrospective cohort analysis.
Niikura R, Hayakawa Y, Hirata Y, Yamada A, Fujishiro M, Koike K. 
Gut. 2018 Oct;67(10):1908-1910.

24) β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer.
Renz BW, Takahashi R, Tanaka T, Macchini M, Hayakawa Y, Dantes Z, Maurer HC, Chen X, Jiang Z, Westphalen CB, Ilmer M, Valenti G, Mohanta SK, Habenicht AJR, Middelhoff M, Chu T, Nagar K, Tailor Y, Casadei R, Di Marco M, Kleespies A, Friedman RA, Remotti H, Reichert M, Worthley DL, Neumann J, Werner J, Iuga AC, Olive KP, Wang TC.
Cancer Cell. 2018 Jan 8;33(1):75-90.e7.

25) Expression of Gastric Markers Is Associated with Malignant Potential of Nonampullary Duodenal Adenocarcinoma.
Minatsuki C, Yamamichi N, Inada KI, Takahashi Y, Sakurai K, Shimamoto T, Tsuji Y, Shiogama K, Kodashima S, Sakaguchi Y, Niimi K, Ono S, Niwa T, Ohata K, Matsuhashi N, Ichinose M, Fujishiro M, Tsutsumi Y, Koike K.
Dig Dis Sci. 2018 Oct;63(10):2617-2625.

26) Preventive measures against stricture after esophageal endoscopic submucosal dissection: Halfway through the journey to the best method.
Tsuji Y, Sakaguchi Y, Fujishiro M, Koike K.
Dig Endosc. 2018 Sep;30(5):600-601.

27) Peribiliary Glands as the Cellular Origin of Biliary Tract Cancer.
Nakagawa H, Hayata Y, Yamada T, Kawamura S, Suzuki N, Koike K.
Int J Mol Sci. Jun 12;19(6):1745.

28) Overexpression of HER2 in the pancreas promotes development of intraductal papillary mucinous neoplasms in mice
Shibata W, Kinoshita H, Hikiba Y, Sato T, Ishii Y, Sue S, Sugimori M, Suzuki N, Sakitani K, Ijich Mori R, Endo I, Maeda S.
Sci Rep. Apr 18;8(1):6150

29) Nectin1 expression is frequently decreased in gastric cancers.
Takahashi Y, Yamamichi N, Inada KI, Shiogama K, Sakurai K, Takeuchi C, Mizutani Y, Tsutsumi
Pathol Int. 2018 Oct;68(10):557-562.

30) Serum anti-Helicobacter pylori antibody titer and its association with gastric nodularity, atrophy, and age: A cross-sectional study.
Toyoshima O, Nishizawa T, Sakitani K, Yamakawa T, Takahashi Y, Yamamichi N, Hata K, Seto Y, Koike K, Watanabe H, Suzuki H.
World J Gastroenterol. 2018 Sep 21;24(35):4061-4068.

31) Decline in perception of acid regurgitation symptoms from gastroesophageal reflux disease in diabetes mellitus patients
Sakitani K, Suzuki N*, Ihara S, Hirata Y, Kawazu S, Iwamoto Y, Koike K.
PLoS One. Mar 15;13(3):e0194466


32) Transduced caudal-type homeobox (CDX) 2/CDX1 can induce growth inhibition on CDX-deficient gastric cancer by rapid intestinal differentiation.
Nakayama C, Yamamichi N, Tomida S, Takahashi Y, Kageyama-Yahara N, Sakurai K, Takeuchi C, Inada KI, Shiogama K, Nagae G, Ono S, Tsuji Y, Niimi K, Fujishiro M, Aburatani H, Tsutsumi Y, Koike K.
Cancer Sci. 2018 Dec;109(12):3853-3864.

1) Bone Marrow Myeloid Cells Regulate Myeloid-Biased Hematopoietic Stem Cells via a Histamine-Dependent Feedback Loop.

Chen X, Deng H, Churchill MJ, Luchsinger LL, Du X, Chu TH, Friedman RA, Middelhoff M, Ding H, Tailor YH, Wang ALE, Liu H, Niu Z, Wang H, Jiang Z, Renders S, Ho SH, Shah SV, Tishchenko P, Chang W, Swayne TC, Munteanu L, Califano A, Takahashi R, Nagar KK, Renz BW, Worthley DL, Westphalen CB, Hayakawa Y, Asfaha S, Borot F, Lin CS, Snoeck HW, Mukherjee S, Wang TC.

Cell Stem Cell. 2017 Dec 7;21(6):747-760.

 

2)　CXCR4-expressing Mist1+ progenitors in the gastric antrum contribute to gastric cancer development.

Sakitani K, Hayakawa Y, Deng H, Ariyama H, Kinoshita H, Konishi M, Ono S, Suzuki N, Ihara S, Niu Z, Kim W, Tanaka T, Liu H, Chen X, Tailor Y, Fox JG, Konieczny SF, Onodera H, Sepulveda AR, Asfaha S, Hirata Y, Worthley DL, Koike K, Wang TC.

Oncotarget. 2017 Nov 10;8(67):111012-111025.

 

3）Associations between drugs and small-bowel mucosal bleeding: A multicenter capsule-endoscopy study.

Niikura R, Yamada A, Maki K, Nakamura M, Watabe H, Fujishiro M, Oka S, Esaki M, Fujimori S, Nakajima A, Ohmiya N, Matsumoto T, Tanaka S, Koike K, Sakamoto C.　

Dig Endosc. 2017 Jul 18. doi: 10.1111/den.12922. [Epub ahead of print]　PMID:28719079

 

4) Evaluation of endoscopic submucosal dissection using a new endosurgical knife DN-D2718B: a first clinical feasibility study.

Sakaguchi Y, Tsuji Y, Fujishiro M, Kataoka Y, Saito I, Shichijo S, Minatsuki C, Asada-Hirayama I, Yamaguchi D, Niimi K, Ono S, Kodashima S, Yamamichi N, Koike K. 

Endosc Int Open. 2017 Jul;5(7):E670-E674. doi: 10.1055/s-0043-111720. Epub 2017 Jul 6. PubMed PMID:28691052; PubMed Central PMCID: PMC5500109.

5）First progress report on the Japan Endoscopy Database (JED) project.

Kodashima S, Tanaka K, Matsuda K, Fujishiro M, Saito Y, Ohtsuka K, Oda I, Katada C, Kato M, Kida M, Kobayashi K, Hoteya S, Horimatsu T, Matsuda T, Muto M, Yamamoto H, Ryozawa S, Iwakiri R, Kutsumi H, Miyata H, Kato M, Haruma K, Fujimoto K, Uemura N, Kaminishi M, Tajiri H.

 Dig Endosc. 2017 Sep 8. doi: 10.1111/den.12963

6）Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis.　

Yamada A, Niikura R, Maki K, Nakamura M, Watabe H, Fujishiro M, Oka S, Fujimori S, Nakajima A, Ohmiya N, Matsumoto T, Tanaka S, Koike K, Sakamoto C.

PLoS One. 2017 Aug 3;12(8):e0182586. doi: 10.1371/journal.pone.0182586. eCollection 2017.

PMID:28771618

 

7)　Metaplasia in the Stomach-Precursor of Gastric Cancer?

Kinoshita H, Hayakawa Y, Koike K.

Int J Mol Sci. 2017 Sep 27;18(10). pii: E2063. doi: 10.3390/ijms18102063.

 

8) Dclk1-expressing tuft cells: Critical modulators of the intestinal niche? 

Middelhoff M, Westphalen CB, Hayakawa Y, Yan KS, Gershon MD, Wang TC, Quante M. 

Am J Physiol Gastrointest Liver Physiol. 2017 Jul 6:ajpgi.00073.2017.

9)　Nerves switch on angiogenic metabolism.

Hayakawa Y, Wang TC.

Science. 2017 Oct 20;358(6361):305-306. doi: 10.1126/science.aaq0365.

 

10) A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and Significance. 

Spechler SJ, Merchant JL, Wang TC, Chandrasoma P, Fox JG, Genta RM, Goldenring JR, Hayakawa Y, Kuipers EJ, Lund PK, McKeon F, Mills JC, Odze RD, Peek RM Jr, Pham T, Que J, Rustgi AK, Shaheen NJ, Shivdasani RA, Souza RF, Storz P, Todisco A, Wang DH, Wright NA.  

Gastroenterology. 2017 Jul;153(1):e6-e13.

11) TGF-β in inflammatory bowel disease: a key　regulator of immune cells, epithelium, and the intestinal microbiota. 

Ihara S, Hirata Y, Koike K.  

J Gastroenterol. 2017 Jul;52(7):777-787 doi: 10.1007/s00535-017-1350-1. Review. PubMed PMID: 28534191.

 

12） Is it possible to perform gastric endoscopic submucosal dissection without discontinuation of a single antiplatelet of thienopyridine derivatives?　

Ono S, Myojo M, Harada H, Tsuji K, Murakami D, Suehiro S, Doyama H, Ando J, Saito I, Fujishiro M, Komuro I, Koike K.　

Endosc Int Open. 2017 Sep;5(9):E943-E949. doi: 10.1055/s-0043-116381. Epub 2017 Sep 13.　PMID: 28924604

 

13）Erratum: Evaluation of image-enhanced endoscopic technology using advanced diagnostic endoscopy for the detection of early gastric cancer: a pilot study.

Yamaguchi D, Kodashima S, Fujishiro M, Ono S, Niimi K, Mochizuki S, Tsuji Y, Asada-Hirayama I, Sakaguchi Y, Shichijo S, Minatsuki C, Yamamichi N, Koike K.　

Endosc Int Open. 2017 Sep;5(9):C2. doi: 10.1055/s-0043-119930. Epub 2017 Sep 22.　PMID: 28948208

 

14）Recent Development of Techniques and Devices in Colorectal Endoscopic Submucosal Dissection.

Mizutani H, Ono S, Ohki D, Takeuchi C, Yakabi S, Kataoka Y, Saito I, Sakaguchi Y, Minatsuki C, Tsuji Y, Niimi K, Kodashima S, Yamamichi N, Fujishiro M, Koike K.　　

Clin Endosc. 2017 Nov;50(6):562-568. doi: 10.5946/ce.2017.108. Epub 2017 Nov 30. Review.　PMID: 29207854

15) Prevalence of pks-positive Escherichia coli in Japanese patients with or without colorectal cancer. 

Shimpoh T, Hirata Y, Ihara S, Suzuki N, Kinoshita H, Hayakawa Y, Ota Y, Narita A, Yoshida S, Yamada A, Koike K. 

Gut Pathog. 2017 Jun　12;9:35. doi: 10.1186/s13099-017-0185-x. eCollection 2017. PubMed PMID: 28616082;

 

16)　Isthmus Progenitors, Not Chief Cells, Are the Likely Origin of Metaplasia in eR1-CreERT; LSL-KrasG12D Mice.

Hayakawa Y, Wang TC.

Gastroenterology. 2017 Jun; 152(8): 2078-2079.

17) Columnar Metaplasia in Three Types of Surgical Mouse Models of Esophageal Reflux. 

Terabe F, Aikou S, Aida J, Yamamichi N, Kaminishi M, Takubo K, Seto Y, Nomura S.

Cell Mol Gastroenterol Hepatol. 2017 Apr 4;4(1):115-123. doi: 10.1016/j.jcmgh.2017.03.009. eCollection 2017 Jul. PubMed PMID: 28593183; PubMed Central PMCID: PMC5453905.

 

18）Colonoscopy reduces colorectal cancer mortality: A multicenter, long-term, colonoscopy-based cohort study.

Niikura R, Hirata Y, Suzuki N, Yamada A, Hayakawa Y, Suzuki H, Yamamoto S, Nakata R, Komatsu J, Okamoto M, Kodaira M, Shinozaki T, Fujishiro M, Watanabe T, Koike K.

PLoS One. 2017 Sep 28;12(9):e0185294. doi: 10.1371/journal.pone.0185294. eCollection 2017.　PMID: 28957370

 

19）Long-term proton pump inhibitor use is a risk factor of gastric cancer after treatment for Helicobacter pylori: a retrospective cohort analysis.

Niikura R, Hayakawa Y, Hirata Y, Yamada A, Fujishiro M, Koike K.　　

Gut. 2017 Dec 22. pii: gutjnl-2017-315710. doi: 10.1136/gutjnl-2017-315710. [Epub ahead of print] No abstract available.　PMID: 29273641

 

20) Analyzing the usefulness of the new anti-Helicobacter pylori serum antibody reagents: H. pylori-LATEX "SEIKEN"and H. pylori IgG "SEIKEN". 

Gondo K, Takahashi Y, Yamamichi N, Kakimoto H, Wada R, Mitsushima T.

Journal of Gastrointestinal Cancer Screening. 2017; 55: 547-554.

21) Laparoscopic and endoscopic cooperative surgery for gastrointestinal tumor. 

Niimi K, Ishibashi R, Mitsui T, Aikou S, Kodashima S, Yamashita H, Yamamichi N, Hirata Y, Fujishiro M, Seto Y, Koike K.

Ann Transl Med. 2017 Apr;5(8):187. doi: 10.21037/atm.2017.03.35. Review. PubMed PMID: 28616402; PubMed Central PMCID: PMC5464944.

22) Isthmus Stem Cells Are the Origins of Metaplasia in the Gastric Corpus. 

Hayakawa Y, Fox JG, Wang TC. 

Cell Mol Gastroenterol Hepatol. 2017 Mar 6;4(1):89-94. 

23) Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands. 

Nakagawa H, Suzuki N, Hirata Y, Hikiba Y, Hayakawa Y, Kinoshita H, Ihara S, Uchino K, Nishikawa Y, Ijichi H, Otsuka M, Arita J, Sakamoto Y, Hasegawa K, Kokudo N, Tateishi K, Koike K. 

Proc Natl Acad Sci U S A. 2017 May 9;114(19):E3806-E3815..

24) Diagnostic capability of colon capsule endoscopy for advanced colorectal cancer: A pilot study. 

Ota Y, Yamada A, Kobayashi Y, Niikura R, Shimpoh T, Narita A, Yoshida S, Suzuki N, Watabe H, Hirata Y, Ishihara S, Sunami E, Watanabe T, Koike K. 

Dig Endosc. 2017 Mar 10. doi: 10.1111/den.12862. [Epub ahead of print] PubMed PMID: 28295697.

25) Updated evidence on endoscopic resection of early gastric cancer from Japan. 

Fujishiro M, Yoshida S, Matsuda R, Narita A, Yamashita H, Seto Y.

Gastric Cancer. 2017 Mar;20(Suppl 1):39-44. doi: 10.1007/s10120-016-0647-8. Epub 2016 Oct 4. Review. PubMed PMID: 27704225. 

26) Gastric polyps diagnosed by double-contrast upper gastrointestinal barium X-ray radiography mostly arise from the Helicobacter pylori-negative stomach with low risk of gastric cancer in Japan. 

Takeuchi C, Yamamichi N, Shimamoto T, Takahashi Y, Mitsushima T, Koike K.

Gastric Cancer. 2017 Mar;20(2):314-321. doi:10.1007/s10120-016-0607-3. Epub 2016 Mar 14. PubMed PMID: 26972573.

27) The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse Models. 

Hayakawa Y, Fox JG, Wang TC. 

Cell Mol Gastroenterol Hepatol. 2017 Feb 20;3(3):331-338.

28) Association between gastric cancer and the Kyoto Classification of Gastritis. 

Shichijo S, Hirata Y, Niikura R, Hayakawa Y, Yamada A, Koike K.

J Gastroenterol Hepatol. 2017 Feb 20. doi: 10.1111/jgh.13764. [Epub ahead of print] PubMed PMID: 28217843.

29) The incidence of post-colonoscopy colorectal cancer: a retrospective long-term cohort study using a colonoscopy database. 

Nakada A, Niikura R, Yamada A, Yoshida S, Hirata Y, Koike K. 

Int J Colorectal Dis. 2017 Jan 14. doi: 10.1007/s00384-017-2757-0. [Epub ahead of print] PubMed PMID: 28091843.

 

30)　Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling.

Hayakawa Y, Sakitani K, Konishi M, Asfaha S, Niikura R, Tomita H, Renz BW, Tailor Y, Macchini M, Middelhoff M, Jiang Z, Tanaka T, Dubeykovskaya ZA, Kim W, Chen X, Urbanska AM, Nagar K, Westphalen CB, Quante M, Lin CS, Gershon MD, Hara A, Zhao CM, Chen D, Worthley DL, Koike K, Wang TC.

 Cancer Cell. 2017 Jan 9; 31(1): 21-34.

 

31)　Laparoscopic and endoscopic cooperative surgery for gastrointestinal tumor.

 Niimi K, R Ishibashi, T Mitsui, S Aikou, S Kodashima, H Yamashita, N Yamamichi, Y Hirata, M Fujishiro, Y Seto, K Koike.

Ann Transl Med 5 (8):187.

 

32) Colonoscopy reduces colorectal cancer mortality: A multicenter, long-term, colonoscopy-based cohort study

Niikura R, Hirata Y, Suzuki N, Yamada A, Hayakawa Y, Suzuki H, Yamamoto S, Nakata R, Komatsu J, Okamoto M, Kodaira M, Shinozaki T, Fujishiro M, Watanabe T, Koike K. PLoS One. Sep 28;12(9):e0185294.

 

33) First-Line Helicobacter pylori Eradication withVonoprazan, Clarithromycin, and Metronidazole in Patients Allergic to Penicillin

Sue S, Suzuki N, Shibata W, Sasaki T, Yamada H, Kaneko H, Tamura T, Ishii T, Kondo M, Maeda S.

Gastroenterol Res Pract.  2017;2017:2019802. doi: 10.1155/2017/2019802. Epub 2017 Oct 18.

 

34)　c-Jun N-terminal kinase in pancreatic tumor stroma augments tumor development in mice Sato T, Shibata W, Hikiba Y, Kaneta Y, Suzuki N, Ihara S, Ishii Y, Sue S, Kameta E, Sugimori M, Yamada H, Kaneko H, Sasaki T, Ishii T, Tamura T, Kondo M, Maeda S. Cancer Sci. Nov;108(11):2156-2165

 

35) Repression of MicroRNA Function Mediates Inflammation-associated Colon Tumorigenesis

Yoshikawa T, Wu J, Otsuka M, Kishikawa T, Suzuki N, Takata A, Ohno M, Ishibashi R, Yamagami M, Nakagawa R, Kato N, Miyazawa M, Han J, Koike K.

Gastroenterology. Feb;152(3):631-643

PMID: 29181022

 

1) Gastrin and upper GI cancers. 

Hayakawa Y, Chang W, Jin G, Wang TC. 

Curr Opin Pharmacol. 2016 Dec;31:31-37. 

2) Diagnostic and Therapeutic Endoscopic Retrograde Cholangiography Using a Short-Type Double-Balloon Endoscope in Patients With Altered Gastrointestinal Anatomy: A Multicenter Prospective Study in Japan. 

Shimatani M, Hatanaka H, Kogure H, Tsutsumi K, Kawashima H, Hanada K, Matsuda T, Fujita T, Takaoka M, Yano T, Yamada A, Kato H, Okazaki K, Yamamoto H, Ishikawa H, Sugano K; Japanese DB-ERC Study Group: 

Am J Gastroenterol. 2016 Dec;111(12):1750-1758. doi: 10.1038/ajg.2016.420. Epub 2016 Sep 27. PMID:27670601

3) Current state of practice for colonic diverticular bleeding in 37 hospitals in Japan: A multicenter questionnaire study. 

Niikura R, Nagata N, Doyama H, Ota R, Ishii N, Mabe K, Nishida T, Hikichi T, Sumiyama K, Nishikawa J, Uraoka T, Kiyotoki S, Fujishiro M, Koike K. 

World J Gastrointest Endosc. 2016 Dec 16;8(20):785-794. doi: 10.4253/wjge.v8.i20.785. PMID:28042393

4) Factors predicting adverse events associated with therapeutic colonoscopy for colorectal neoplasia: a retrospective nationwide study in Japan. 

Niikura R, Yasunaga H, Yamada A, Matsui H, Fushimi K, Hirata Y, Koike K. 

Gastrointest Endosc. 2016 Dec;84(6):971-982.e6. doi: 10.1016/j.gie.2016.05.013. PubMed PMID: 27189658.

5) High impact of methylation accumulation on metachronous gastric cancer: 5-year

follow-up of a multicentre prospective cohort study. 

Maeda M, Nakajima T, Oda I, Shimazu T, Yamamichi N, Maekita T, Asada K, Yokoi C, Ando T, Yoshida T, Nanjo S, Fujishiro M, Gotoda T, Ichinose M, Ushijima T.

Gut. 2016 Dec 21. pii:gutjnl-2016-313387. doi: 10.1136/gutjnl-2016-313387. [Epub ahead of print] PubMed PMID: 28003322.

6) Response. 

Hirata Y, Shichijo S, Koike K. 

Gastrointest Endosc. 2016 Nov;84(5):876-877. doi: 10.1016/j.gie.2016.07.004. PubMed PMID: 27424194. 

7) Successful endoscopic treatment of stapled J-pouch ileoanal canal anastomotic hemorrhage by argon plasma coagulation: a case report. 

Nishikawa T, Hata K, Yoshida S, Murono K, Yasuda K, Otani K, Tanaka T, Kiyomatsu T, Kawai K, Nozawa H, Ishihara S, Koike K, Watanabe T. 

J Med Case Rep. 2016 Nov 3;10(1):309. PMID: 27809887

8) Targeting the complex interactions between microbiota, host epithelial and immune cells in inflammatory bowel disease. 

Hirata Y, Ihara S, Koike K. 

Pharmacol Res. 2016 Nov;113(Pt A):574-584. doi: 10.1016/j.phrs.2016.09.044. Review. PubMed PMID: 27702681.

9) Development and Validation of a Risk Scoring System for Severe Acute Lower Gastrointestinal Bleeding. 

Aoki T, Nagata N, Shimbo T, Niikura R, Sakurai T, Moriyasu S, Okubo H, Sekine K, Watanabe K, Yokoi C, Yanase M, Akiyama J, Mizokami M, Uemura N. 

Clin Gastroenterol Hepatol. 2016 Nov;14(11):1562-1570.e2. doi: 10.1016/j.cgh.2016.05.042. Epub 2016 Jun 14. PMID: 27311620

10) Characteristics of gastric cancer detected within 1 year after successful eradication of Helicobacter pylori. 

Nishizawa T, Suzuki H, Arano T, Yoshida S, Yamashita H, Hata K, Kanai T, Yahagi N, Toyoshima O. 

J Clin Biochem Nutr. 2016 Nov;59(3):226-230. Epub 2016 Aug 24.

11) Histologic intestinal metaplasia and endoscopic atrophy are predictors of gastric cancer development after Helicobacter pylori eradication. 

Shichijo S, Hirata Y, Niikura R, Hayakawa Y, Yamada A, Ushiku T, Fukayama M, Koike K. 

Gastrointest Endosc. 2016 Oct;84(4):618-24. doi: 10.1016/j.gie.2016.03.791. Epub 2016 Mar 16. PubMed PMID: 26995689.

12) Efficacy of triple therapy with esomeprazole, amoxicillin, and sitafloxacin as a third-line Helicobacter pylori eradication regimen. 

Hirata Y, Serizawa T, Shichijo S, Suzuki N, Sakitani K, Hayakawa Y, Yamada A, Koike K.

Int J Infect Dis. 2016 Oct;51:66-69. doi: 10.1016/j.ijid.2016.08.019. PubMed PMID: 27590563.

13) Efficacy of repeat review with flexible spectral imaging color enhancement in patients with no findings by capsule endoscopy. 

Minami-Kobayashi Y, Yamada A, Watabe H, Suzuki H, Hirata Y, Yamaji Y, Yoshida H, Koike K. 

Saudi J Gastroenterol. 2016 Sep-Oct;22(5):385-390. doi: 10.4103/1319-3767.191145. PubMed PMID: 27748326; PubMed Central PMCID: PMC5051224.

14) Vonoprazan versus conventional proton pump inhibitor-based triple therapy as first-line treatment against Helicobacter pylori: A multicenter retrospective study in clinical practice. 

Shichijo S, Hirata Y, Niikura R, Hayakawa Y, Yamada A, Mochizuki S, Matsuo K, Isomura Y, Seto M, Suzuki N, Suzuki H, Yamamoto S, Sugimoto T, Omae T, Okamoto M, Watabe H, Togo G, Takano N, Fukui K, Ito Y, Koike K. 

J Dig Dis. 2016 Oct;17(10):670-675. doi: 10.1111/1751-2980.12398. PubMed PMID: 27534444.

15) Current Practices in the Management of Antithrombotic Therapy During the Periendoscopic Period for Patients With Cardiovascular Disease. 

Ono S, Saito I, Ikeda Y, Fujishiro M, Komuro I, Koike K.

Int Heart J. 2016 Sep 28;57(5):530-4. doi:10.1536/ihj.16-057. Epub 2016 Sep 1. Review. PubMed PMID: 27581678.

16) Exchange of opinions in Tokyo, 2016 between Japan Gastroenterological Endoscopy Society (JGES) and counterparts from abroad. 

Fujishiro M, Yasuda I.

Dig Endosc. 2016 Sep;28(6):642-4. doi: 10.1111/den.12703. PubMed PMID:27587364.

17) A prospective multicenter study on self-expandable metallic stents as a bridge to surgery for malignant colorectal obstruction in Japan: efficacy and safety in 312 patients. 

Saito S, Yoshida S, Isayama H, Matsuzawa T, Kuwai T, Maetani I, Shimada M, Yamada T, Tomita M, Koizumi K, Hirata N, Kanazawa H, Enomoto T, Sekido H, Saida Y. 

Surg Endosc. 2016 Sep;30(9):3976-86. doi: 10.1007/s00464-015-4709-5. Epub 2015 Dec 18. PMID: 26684205

18) Successful closure of a large perforation during colorectal endoscopic submucosal dissection by application of polyglycolic acid sheets and fibrin glue. 

Sakaguchi Y, Tsuji Y, Yamamichi N, Fujishiro M, Koike K. 

Gastrointest Endosc. 2016 Aug;84(2):374-5. doi: 10.1016/j.gie.2016.03.787. Epub 2016 Mar 14. PubMed PMID: 26989041.

19) Electrohydraulic lithotripsy as a salvage option for stone impaction during double-balloon endoscope-assisted ERCP. 

Hakuta R, Kogure H, Isayama H, Yamada A, Hamada T, Nakai Y, Koike K: 

Gastrointest Endosc. 2016 Jul;84(1):177. doi: 10.1016/j.gie.2016.01.065. Epub 2016 Feb 6. PMID:26859867

20) Bleeding after endoscopic submucosal dissection: Risk factors and preventive methods. 

Kataoka Y, Tsuji Y, Sakaguchi Y, Minatsuki C, Asada-Hirayama I, Niimi K, Ono S, Kodashima S, Yamamichi N, Fujishiro M, Koike K.

World J Gastroenterol. 2016 Jul 14;22(26):5927-35. doi: 10.3748/wjg.v22.i26.5927. Review. PubMed PMID: 27468187; PubMed Central PMCID: PMC4948274.

21)  Atrophic gastritis and enlarged gastric folds diagnosed by double-contrast upper gastrointestinal barium X-ray radiography are useful to predict future gastric cancer development based on the 3-year prospective observation. 

Yamamichi N, Hirano C, Ichinose M, Takahashi Y, Minatsuki C, Matsuda R, Nakayama C, Shimamoto T, Kodashima S, Ono S, Tsuji Y, Niimi K, Sakaguchi Y, Kataoka Y, Saito I, Asada-Hirayama I, Takeuchi C, Yakabi S, Kaikimoto H, Matsumoto Y, Yamaguchi D, Kageyama-Yahara N, Fujishiro M, Wada R, Mitsushima T, Koike K.

Gastric Cancer. 2016 Jul;19(3):1016-22. doi: 10.1007/s10120-015-0558-0. Epub 2015 Oct 20. PubMed PMID: 26486508.

22) Incidence of and risk factors for metachronous gastric cancer after endoscopic resection and successful Helicobacter pylori eradication: results of a large-scale, multicenter cohort study in Japan. 

Mori G, Nakajima T, Asada K, Shimazu T, Yamamichi N, Maekita T, Yokoi C, Fujishiro M, Gotoda T, Ichinose M, Ushijima T, Oda I. 

Gastric Cancer. 2016 Jul;19(3):911-8. doi: 10.1007/s10120-015-0544-6. Epub 2015 Sep 29. PubMed PMID: 26420267.

23) Assessment of an electronic learning system for colon capsule endoscopy: a pilot study. 

Watabe H, Nakamura T, Yamada A, Kakugawa Y, Nouda S, Terano A

J Gastroenterol. 2016 Jun;51(6):579-85. doi: 10.1007/s00535-015-1134-4. Epub 2015 Nov 2. PMID: 26525538

24) Association Between Colorectal Cancer and Atherosclerotic Diseases: A Study Using a National Inpatient Database in Japan. 

Yamaji Y, Yasunaga H, Hirata Y, Yamada A, Yoshida S, Horiguchi H, Fushimi K, Koike K. 

Dig Dis Sci. 2016 Jun;61(6):1677-85. doi: 10.1007/s10620-016-4041-5. Epub 2016 Feb 1. PubMed PMID: 26831490.

25) Re-bleeding After Endoscopic Hemostasis for PepticUlcer Bleeding: Is eNough SAID or Are Other Factors Important? 

Fujishiro M, Ikeda Y. 

Dig Dis Sci. 2016 Jun;61(6):1424-5. doi: 10.1007/s10620-016-4098-1. PubMed PMID: 26971087.

26) TGF-β Signaling in Dendritic Cells Governs Colonic Homeostasis by Controlling Epithelial Differentiation and the Luminal Microbiota. 

Ihara S, Hirata Y, Serizawa T, Suzuki N, Sakitani K, Kinoshita H, Hayakawa Y, Nakagawa H, Ijichi H, Tateishi K, Koike K. 

J Immunol. 2016 Jun 1;196(11):4603-13. doi: 10.4049/jimmunol.1502548. Epub 2016 Apr 22. PubMed PMID: 27183608.

27) Magnifying endoscopy with narrow-band imaging is more accurate for determination of horizontal extent of early gastric cancers than chromoendoscopy. 

Asada-Hirayama I, Kodashima S, Sakaguchi Y, Ono S, Niimi K, Mochizuki S, Tsuji Y, Minatsuki C, Shichijo S, Matsuzaka K, Ushiku T, Fukayama M, Yamamichi N, Fujishiro M, Koike K.

Endosc Int Open. 2016 Jun;4(6):E690-8. doi: 10.1055/s-0042-107068. PubMed PMID: 27556080; PubMed Central PMCID: PMC4993874.

28) Rapid and sensitive detection of early esophageal squamous cell carcinoma with fluorescence probe targeting dipeptidylpeptidase IV. 

Onoyama H, Kamiya M, Kuriki Y, Komatsu T, Abe H, Tsuji Y, Yagi K, Yamagata Y, Aikou S, Nishida M, Mori K, Yamashita H, Fujishiro M, Nomura S, Shimizu N, Fukayama M, Koike K, Urano Y, Seto Y.

Sci Rep. 2016 Jun 1;6:26399. doi: 10.1038/srep26399. PubMed PMID: 27245876; PubMed Central PMCID: PMC4887889.

29) Safety of Regular-Dose Imatinib Therapy in Patients with Gastrointestinal Stromal Tumors Undergoing Dialysis. 

Niikura R, Serizawa T, Yamada A, Yoshida S, Tanaka M, Hirata Y, Koike K. 

Case Rep Gastroenterol. 2016 May 19;10(1):17-23. doi: 10.1159/000443267. PubMed PMID: 27403097; PubMed Central PMCID: PMC4929395.

30) Guidelines for endoscopic management of non-variceal upper gastrointestinal bleeding. 

Fujishiro M, Iguchi M, Kakushima N, Kato M, Sakata Y, Hoteya S, Kataoka M, Shimaoka S, Yahagi N, Fujimoto K. 

Dig Endosc. 2016 May;28(4):363-78. doi: 10.1111/den.12639. Epub 2016 Apr 5. Review. PubMed PMID: 26900095.

31) Endoscopic ultrasound-guided fine-needle aspiration skill acquisition of gastrointestinal submucosal tumor by trainee endoscopists: A pilot study. 

Niimi K, Goto O, Kawakubo K, Nakai Y, Minatsuki C, Asada-Hirayama I, Mochizuki S, Ono S, Kodashima S, Yamamichi N, Isayama H, Fujishiro M, Koike K.

Endosc Ultrasound. 2016 May-Jun;5(3):157-64. doi: 10.4103/2303-9027.183970. PubMed PMID: 27386472; PubMed Central PMCID: PMC4918298.

32) Oesophageal Adenocarcinoma and Gastric Cancer: Should we Mind the Gap? 

Hayakawa Y, Sethi N, Sepulveda AR, Bass AJ, Wang TC. 

Nat Rev Cancer. 2016 Apr 26;16(5):305-18.

33) New predictive model of rebleeding during follow-up of patents with obscure gastrointestinal bleeding: A multicenter cohort study. 

Niikura R, Yamada A, Nagata N, Kobayashi Y, Okamoto M, Mitsuno Y, Ogura K, Yoshida S, Shimbo T, Hirata Y, Koike K: 

J Gastroenterol Hepatol. 2016 Apr;31(4):752-60. doi: 10.1111/jgh.13201. PMID:26487158

34) Tumor Content Chart-Assisted HER2/CEP17 Digital PCR Analysis of Gastric Cancer Biopsy Specimens. 

Matsusaka K, Ishikawa S, Nakayama A, Ushiku T, Nishimoto A, Urabe M, Kaneko N, Kunita A, Kaneda A, Aburatani H, Fujishiro M, Seto Y, Fukayama M.

PLoS One. 2016 Apr 27;11(4):e0154430. doi: 10.1371/journal.pone.0154430. eCollection 2016. PubMed PMID: 27119558; PubMed Central PMCID: PMC4847903.

35) Triamcinolone Injection and Shielding with Polyglycolic Acid Sheets and Fibrin Glue for Postoperative Stricture Prevention after Esophageal Endoscopic Resection: A Pilot Study. 

Sakaguchi Y, Tsuji Y, Fujishiro M, Kataoka Y, Takeuchi C, Yakabi S, Saito I, Shichijo S, Minatsuki C, Asada-Hirayama I, Yamaguchi D, Niimi K, Ono S, Kodashima S, Yamamichi N, Koike K.

Am J Gastroenterol. 2016 Apr;111(4):581-3. doi: 10.1038/ajg.2016.60. PubMed PMID: 27125718.

36) Comparative analysis of upper gastrointestinal endoscopy, double-contrast upper gastrointestinal barium X-ray radiography, and the titer of serum anti-Helicobacter pylori IgG focusing on the diagnosis of atrophic gastritis. 

Yamamichi N, Hirano C, Takahashi Y, Minatsuki C, Nakayama C, Matsuda R, Shimamoto T, Takeuchi C, Kodashima S, Ono S, Tsuji Y, Fujishiro M, Wada R, Mitsushima T, Koike K.

Gastric Cancer. 2016 Apr;19(2):670-5. doi: 10.1007/s10120-015-0515-y. Epub 2015 Jul 30. PubMed PMID: 26223472. 

37) Acute Middle Gastrointestinal Bleeding Risk Associated with NSAIDs, Antithrombotic Drugs, and PPIs: A Multicenter Case-Control Study. 

Nagata N, Niikura R, Yamada A, Sakurai T, Shimbo T, Kobayashi Y, Okamoto M, Mitsuno Y, Ogura K, Hirata Y, Fujimoto K, Akiyama J, Uemura N, Koike K. 

PLoS One. 2016 Mar 15;11(3):e0151332. doi: 10.1371/journal.pone.0151332. eCollection 2016. PubMed PMID: 26978517; PubMed Central PMCID: PMC4792424.

38) Outcome of salvage surgery for colorectal cancer initially treated by upfront endoscopic therapy. 

Nozawa H, Ishihara S, Fujishiro M, Kodashima S, Ohtani K, Yasuda K, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Hata K, Kazama S, Sunami E, Kitayama J, Watanabe T.

Surgery. 2016 Mar;159(3):713-20. doi: 10.1016/j.surg.2015.09.008. Epub 2015 Oct 21. PubMed PMID: 26477474.

39) Guidelines for endoscopic submucosal dissection and endoscopic mucosal resection for early gastric cancer. 

Ono H, Yao K, Fujishiro M, Oda I, Nimura S, Yahagi N, Iishi H, Oka M, Ajioka Y, Ichinose M, Matsui T.

Dig Endosc. 2016 Jan;28(1):3-15. doi: 10.1111/den.12518. Epub 2015 Oct 4. PubMed PMID: 26234303.

40) Registration Committee for Esophageal Cancer of the Japan Esophageal Society. Comprehensive Registry of Esophageal Cancer in Japan, 2009. 

Tachimori Y, Ozawa S, Numasaki H, Fujishiro M, Matsubara H, Oyama T, Shinoda M, Toh Y, Udagawa H, Uno T

Esophagus. 2016;13:110-137. Epub 2016 Mar 29. PubMed PMID: 27110229; PubMed Central PMCID: PMC4824839.

41) Registration Committee for Esophageal Cancer of the Japan Esophageal Society. Efficacy of lymph node dissection by node zones according to tumor location for esophageal squamous cell carcinoma. 

Tachimori Y, Ozawa S, Numasaki H, Matsubara H, Shinoda M, Toh Y, Udagawa H, Fujishiro M, Oyama T, Uno T

Esophagus. 2016;13:1-7. Epub 2015 Nov 17. PubMed PMID: 26752982; PubMed Central PMCID:

PMC4698372.

1) Helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease: a large-scale cross-sectional study in Japan.

Okushin K, Takahashi Y, Yamamichi N, Shimamoto T, Enooku K, Fujinaga H, Tsutsumi T, Shintani Y, Sakaguchi Y, Ono S, Kodashima S, Fujishiro M, Moriya K, Yotsuyanagi H, Mitsushima T, Koike K.

BMC Gastroenterol. 2015 Feb 19;15(1):25. doi: 10.1186/s12876-015-0247-9.

 

2) Trend and risk factors of diverticulosis in Japan: age, gender, and lifestyle/metabolic-related factors may cooperatively affect on the colorectal diverticula formation.

Yamamichi N, Shimamoto T, Takahashi Y, Sakaguchi Y, Kakimoto H, Matsuda R, Kataoka Y, Saito I, Tsuji Y, Yakabi S, Takeuchi C, Minatsuki C, Niimi K, Asada-Hirayama I, Nakayama C, Ono S, Kodashima S, Yamaguchi D, Fujishiro M, Yamaji Y, Wada R, Mitsushima T, Koike K.

PLoS One. 2015 Apr 10;10(4):e0123688. doi: 10.1371/journal.pone.0123688. eCollection 2015.

 

3) Impact of fecal occult blood on obscure gastrointestinal bleeding: observational study.

Kobayashi Y, Watabe H, Yamada A, Suzuki H, Hirata Y, Yamaji Y, Yoshida H, Koike K.

World J Gastroenterol. 2015 Jan 7;21(1):326-32. doi: 10.3748/wjg.v21.i1.326.

 

4) Characterization of a new small bowel adenocarcinoma cell line and screening of anti-cancer drug against small bowel adenocarcinoma.

Suzuki H, Hirata Y, Suzuki N, Ihara S, Sakitani K, Kobayashi Y, Kinoshita H, Hayakawa Y, Yamada A, Watabe H, Tateishi K, Ikenoue T, Yamaji Y, Koike K.

Am J Pathol. 2015 Feb;185(2):550-62. doi: 10.1016/j.ajpath.2014.10.006. Epub 2014 Dec 2.

 

5) Polyglycolic acid sheets and fibrin glue decrease the risk of bleeding after endoscopic submucosal dissection of gastric neoplasms (with video).

Tsuji Y, Fujishiro M, Kodashima S, Ono S, Niimi K, Mochizuki S, Asada-Hirayama I, Matsuda R, Minatsuki C, Nakayama C, Takahashi Y, Sakaguchi Y, Yamamichi N, Koike K.

Gastrointest Endosc. 2015 Apr;81(4):906-12. doi: 10.1016/j.gie.2014.08.028. Epub 2014 Oct 29.

 

6) Demonstration of the usefulness of epigenetic cancer risk prediction by a multicentre prospective cohort study.

Asada K, Nakajima T, Shimazu T, Yamamichi N, Maekita T, Yokoi C, Oda I, Ando T, Yoshida T, Nanjo S, Fujishiro M, Gotoda T, Ichinose M, Ushijima T.

Gut. 2015 Mar;64(3):388-96. doi: 10.1136/gutjnl-2014-307094. Epub 2014 Jun 2.

 

7) Polyglycolic acid sheets with fibrin glue can prevent esophageal stricture after endoscopic submucosal dissection.

Sakaguchi Y, Tsuji Y, Ono S, Saito I, Kataoka Y, Takahashi Y, Nakayama C, Shichijo S, Matsuda R, Minatsuki C, Asada-Hirayama I, Niimi K, Kodashima S, Yamamichi N, Fujishiro M, Koike K.

Endoscopy. 2015 Apr;47(4):336-40. doi: 10.1055/s-0034-1390787. Epub 2014 Oct 14.

 

8) Scheduled second-look endoscopy is not recommended after endoscopic submucosal dissection for gastric neoplasms (the SAFE trial): a multicentre prospective randomised controlled non-inferiority trial.

Mochizuki S, Uedo N, Oda I, Kaneko K, Yamamoto Y, Yamashina T, Suzuki H, Kodashima S, Yano T, Yamamichi N, Goto O, Shimamoto T, Fujishiro M, Koike K; SAFE Trial Study Group.

Gut. 2015 Mar;64(3):397-405. doi: 10.1136/gutjnl-2014-307552. Epub 2014 Oct 9.

 

9) Factors affecting in-hospital mortality in patients with lower gastrointestinal tract bleeding: a retrospective study using a national database in Japan.

Niikura R, Yasunaga H, Yamaji Y, Horiguchi H, Fushimi K, Yamada A, Hirata Y, Koike K.

J Gastroenterol. 2015 May;50(5):533-40. doi: 10.1007/s00535-014-0994-3. Epub 2014 Sep 3.

 

10）Video of the Month: A Novel Endoscopic Full-Thickness Resection for Early Gastric Cancer.

Niimi K, Aikou S, Kodashima S, Yagi K, Oya S, Yamaguchi D, Yamashita H, Yamamichi N, Fujishiro M, Koike K, Seto Y.

Am J Gastroenterol. 2015 Nov;110(11):1535. doi: 10.1038/ajg.2015.226. 

11）Preventing esophageal stricture after endoscopic submucosal dissection: steroid injection and shielding with polyglycolic acid sheets and fibrin glue.

Kataoka Y, Tsuji Y, Sakaguchi Y, Kodashima S, Yamamichi N, Fujishiro M, Koike K.

Endoscopy. 2015;47 Suppl 1 UCTN:E473-4. doi: 10.1055/s-0034-1392975. Epub 2015 Oct 14. No abstract available.

12）Foam plombage: a novel technique for optimal fixation of polyglycolic acid sheets positioned using "clip and pull" after esophageal endoscopic submucosal dissection.

Ono S, Sakaguchi Y, Tsuji Y, Kodashima S, Yamamichi N, Fujishiro M, Koike K.

Endoscopy. 2015;47 Suppl 1 UCTN:E435-6. doi: 10.1055/s-0034-1392612. Epub 2015 Sep 23.

 

13）Recent clinical management of antithrombotic agents for gastrointestinal endoscopy after revision of guidelines in Japan.

Ono S, Fujishiro M, Ikeda Y, Komuro I, Koike K.

Dig Endosc. 2015 Sep;27(6):649-56. doi: 10.1111/den.12498. Epub 2015 Jun 17.

 

14）Thienopyridine derivatives as risk factors for bleeding following high risk endoscopic treatments: Safe Treatment on Antiplatelets (STRAP) study.

Ono S, Fujishiro M, Yoshida N, Doyama H, Kamoshida T, Hirai S, Kishihara T, Yamamoto Y, Sakae H, Imagawa A, Hirano M, Koike K.

Endoscopy. 2015 Jul;47(7):632-7. doi: 10.1055/s-0034-1391354. Epub 2015 Jan 15.

 

15）Gastric Metaplasia Induced by Helicobacter pylori Is Associated with Enhanced SOX9 Expression via Interleukin-1 Signaling.

Serizawa T, Hirata Y, Hayakawa Y, Suzuki N, Sakitani K, Hikiba Y, Ihara S, Kinoshita H, Nakagawa H, Tateishi K, Koike K.

Infect Immun. 2015 Dec 7;84(2):562-72. doi: 10.1128/IAI.01437-15.

 

16）Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress.

Sakitani K, Hirata Y, Hikiba Y, Hayakawa Y, Ihara S, Suzuki H, Suzuki N, Serizawa T, Kinoshita H, Sakamoto K, Nakagawa H, Tateishi K, Maeda S, Ikenoue T, Kawazu S, Koike K.

BMC Cancer. 2015 Oct 24;15:795. doi: 10.1186/s12885-015-1789-5.

 

17）Gastric cancer diagnosed after Helicobacter pylori eradication in diabetes mellitus patients.

Sakitani K, Hirata Y, Suzuki N, Shichijo S, Yanai A, Serizawa T, Sakamoto K, Akanuma M, Maeda S, Yamaji Y, Iwamoto Y, Kawazu S, Koike K.

BMC Gastroenterol. 2015 Oct 21;15:143. doi: 10.1186/s12876-015-0377-0.

 

18）Adverse Events during Bowel Preparation and Colonoscopy in Patients with Acute Lower Gastrointestinal Bleeding Compared with Elective Non-Gastrointestinal Bleeding.

Niikura R, Nagata N, Shimbo T, Sakurai T, Aoki T, Moriyasu S, Sekine K, Okubo H, Watanabe K, Yokoi C, Yamada A, Hirata Y, Koike K, Akiyama J, Uemura N.

PLoS One. 2015 Sep 14;10(9):e0138000. doi: 10.1371/journal.pone.0138000. eCollection 2015.

 

19）Association between colorectal polyps and hypertension treatment.

Watanabe Y, Yamaji Y, Kobayashi Y, Yoshida S, Sugimoto T, Yamada A, Watabe H, Hirata Y, Koike K.

J Dig Dis. 2015 Nov;16(11):649-55. doi: 10.1111/1751-2980.12289.

 

20）Endoscopic management of colonic diverticular bleeding.

Yamada A, Niikura R, Yoshida S, Hirata Y, Koike K.

Dig Endosc. 2015 Nov;27(7):720-5. doi: 10.1111/den.12534. Epub 2015 Sep 8. Review.

 

21）Risk factors for small bowel angioectasia: The impact of visceral fat accumulation.

Yamada A, Niikura R, Kobayashi Y, Suzuki H, Yoshida S, Watabe H, Yamaji Y, Hirata Y, Koike K.

World J Gastroenterol. 2015 Jun 21;21(23):7242-7. doi: 10.3748/wjg.v21.i23.7242.

 

22）Neutrophil infiltration and the distribution of intestinal metaplasia is associated with metachronous gastric cancer following endoscopic submucosal dissection.

Sugimoto T, Yamaji Y, Sakitani K, Isomura Y, Yoshida S, Yamada A, Hirata Y, Ogura K, Okamoto M, Koike K.

Can J Gastroenterol Hepatol. 2015 Aug-Sep;29(6):321-5. Epub 2015 Jun 12.

 

23）Distribution of intestinal metaplasia as a predictor of gastric cancer development.

Shichijo S, Hirata Y, Sakitani K, Yamamoto S, Serizawa T, Niikura R, Watabe H, Yoshida S, Yamada A, Yamaji Y, Ushiku T, Fukayama M, Koike K.

J Gastroenterol Hepatol. 2015 Aug;30(8):1260-4. doi: 10.1111/jgh.12946.

 

24）Natural history of bleeding risk in colonic diverticulosis patients: a long-term colonoscopy-based cohort study.

Niikura R, Nagata N, Shimbo T, Aoki T, Yamada A, Hirata Y, Sekine K, Okubo H, Watanabe K, Sakurai T, Yokoi C, Mizokami M, Yanase M, Akiyama J, Koike K, Uemura N.

Aliment Pharmacol Ther. 2015 May;41(9):888-94. doi: 10.1111/apt.13148. Epub 2015 Feb 26.